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Stella+ (GHK-Cu/Estriol/Tretinoin w/ Niacinamide) 3/0.3/0.01% – 30 g Cream is a bioactive skin rejuvenation therapy formulated to address the visible signs of aging through cellular repair, Dermal hormone support, and advanced collagen stimulation.

This custom-formulated cream combines peptides, gentle hormones, and retinoids to restore youthful skin texture and tone while supporting long-term dermal health.

Key Active Ingredients:

GHK-Cu (3%) – a regenerative copper peptide that stimulates collagen, elastin, and glycosaminoglycan synthesis for improved firmness and healing.

Estriol (0.3%) – a mild bioidentical estrogen that helps restore skin thickness, elasticity, and hydration, particularly in mature or hormonally imbalanced skin.

Tretinoin (0.01%) – promotes cell turnover, reduces fine lines, and enhances skin clarity and smoothness.

Niacinamide – improves barrier function, reduces redness, and brightens overall complexion.

How It Works:

This advanced combination works synergistically to revitalize aging skin, improve collagen density, and rebalance hormonal influence on skin integrity. Regular use promotes firmer, more hydrated, and visibly radiant skin.

✅ Benefits:

Boosts collagen and elastin for firmer texture

Reduces fine lines, dryness, and dullness

Enhances cell renewal and elasticity

Supports hormonal balance in mature skin

Smooths and brightens overall tone

✅ Format: 30 g topical cream

✅ Storage: Refrigerate to preserve peptide stability and potency.

✅ Use: Apply as directed by your provider, typically at night to clean, dry skin.

⚠️ Note: For external use only. Use under medical supervision. Avoid contact with eyes.

Topical Cream — Application Instructions

Cleanse the face gently and pat dry before applying
Apply a small, pea-sized amount (approximately 0.5 mL or as directed by the prescriber) evenly across the face, avoiding the immediate eye area, nostrils, and corners of the mouth
Apply once daily in the evening — tretinoin is photosensitive and is best used at night
Allow the cream to absorb fully before applying any additional moisturizer or sunscreen
Apply a broad-spectrum sunscreen of SPF 30 or higher every morning without exception — tretinoin and estriol increase photosensitivity, and sun protection is essential to address potential irritation and hyperpigmentation
Start slowly: if new to tretinoin, apply every other night for the first 2–4 weeks, then advance to nightly use as tolerated
Do not apply to broken, sunburned, irritated, or actively inflamed skin
Avoid contact with the eyes, lips, and mucous membranes; if contact occurs, rinse thoroughly with water
Wash hands after each application
A short adjustment period is normal — mild dryness, flaking, or a sensation of warmth during the first 2–6 weeks is expected with tretinoin use and typically resolves as the skin adapts
Using a gentle, fragrance-free moisturizer 10–15 minutes before applying Stella+ (the "sandwich" technique) can help manage initial retinoid irritation for sensitive skin